Undergraduate Summer Student Job Details
Investigation of the role of GABA and glutamate in perimenopausal depression. An in vivo Magnetic Resonance Spectroscopy study
Dr.Jean-Michel Le Melledo
1E7.11 Walter C MacKenzie Health Sciences Centre
The perimenopause is a period of increased risk of developing an episode of major depression. This transition period is associated with unique fluctuations of female hormones. GABA and glutamate have been suspected to play a major role in the occurrence of depressive symptoms. Female hormones have been shown to impact GABAergic and glutamatergic function in the brain. There is a paucity of biological investigations into the pathophysiology of perimenopausal depression. We are using an MRI machine and Magnetic Resonance Spectroscopy methodology to measure GABA and glutamate levels in the medial prefrontal cortex and the left dorsolateral prefrontal cortex, two brain areas that have been associated with mood dysregulation. The student will participate in the recruitment and the imaging of the research subjects.